Kanye West, Kim Kardashian expecting 1st child

ATLANTIC CITY, N.J. (AP) — A kid for Kimye: Kanye West and Kim Kardashian are expecting their first child.

The rapper announced at a concert Sunday night that his girlfriend is pregnant. He told the crowd of more than 5,000 at Revel Resort‘s Ovation Hall in song form: “Now you having my baby.”

The crowd roared. And so did people on the Internet.

The news instantly went viral on Twitter and Facebook, with thousands posting and commenting on the expecting couple.

Most of the Kardashian clan also tweeted about the news, including Kim’s sisters and mother. Kourtney Kardashian wrote: “Another angel to welcome to our family. Overwhelmed with excitement!”

West, 35, also told concertgoers to congratulate his “baby mom” and that this was the “most amazing thing.”

Representatives for West and Kardashian, 32, didn’t immediately respond to emails about the pregnancy.

The rapper and reality TV star went public in March.

Kardashian married NBA player Kris Humphries in August 2011 and their divorce is not finalized.

West’s Sunday night show was his third consecutive performance at Revel. He took the stage for nearly two hours, performing hits like “Good Life,” ”Jesus Walks” and “Clique” in an all-white ensemble with two band mates.

___

AP Writer Bianca Roach contributed to this report.

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Chinese Firm Is Cleared to Buy American DNA Sequencing Company

Ramin Rahimian for The New York Times

DNA sequencing machines at Complete Genomics in California. The firm dismissed concerns about its acquisition.

The federal government has given national security clearance to the controversial purchase of an American DNA sequencing company by a Chinese firm.

The Chinese firm, BGI-Shenzhen, said in a statement this weekend that its acquisition of Complete Genomics, based in Mountain View, Calif., had been cleared by the federal Committee on Foreign Investment in the United States, which reviews the national security implications of foreign takeovers of American companies. The deal still requires antitrust clearance by the Federal Trade Commission.

Some scientists, politicians and industry executives had said the takeover represented a threat to American competitiveness in DNA sequencing, a technology that is becoming crucial for the development of drugs, diagnostics and improved crops.

The fact that the $117.6 million deal was controversial at all reflects a change in the genomics community.

A decade ago, the Human Genome Project, in which scientists from many nations helped unravel the genetic blueprint of mankind, was celebrated for its spirit of international cooperation. One of the participants in the project was BGI, which was then known as the Beijing Genomics Institute.

But with DNA sequencing now becoming a big business and linchpin of the biotechnology industry, international rivalries and nationalism are starting to move front and center in any acquisition.

Much of the alarm about the deal has been raised by Illumina, a San Diego company that is the market leader in sequencing machines. It has potentially the most to lose from the deal because BGI might buy fewer Illumina products and even become a competitor. Weeks after the BGI deal was announced, Illumina made its own belated bid for Complete Genomics, offering 15 cents a share more than BGI’s bid of $3.15. But Complete Genomics rebuffed Illumina, saying such a merger would never clear antitrust review.

Illumina also hired a Washington lobbyist, the Glover Park Group, to stir up opposition to the deal in Congress. Representative Frank R. Wolf, Republican of Virginia, was the only member of Congress known to have publicly expressed concern.

BGI and Complete Genomics point out that Illumina has long sold its sequencing machines — including a record-setting order of 128 high-end machines — to BGI without raising any security concerns. Sequencing machines have not been subject to export controls like aerospace equipment, lasers, sensors and other gear that can have clear military uses.

“Illumina has never previously considered its business with BGI as ‘sensitive’ in the least,” Ye Yin, the chief operating officer of BGI, said in a November letter to Complete Genomics that was made public in a regulatory filing. In the letter, Illumina was accused of “obvious hypocrisy.”

BGI and Complete said that Illumina was trying to derail the agreement and acquire Complete Genomics itself in order to “eliminate its closest competitor, Complete.”

BGI is already one of the most prolific DNA sequencers in the world, but it buys the sequencing machines it uses from others, mainly Illumina.

Illumina, joined by some American scientists, said it worried that if BGI gained access to Complete’s sequencing technology, the Chinese company might use low prices to undercut the American sequencing companies that now dominate the industry.

Some also said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information that could be used to develop drugs and diagnostic tests. Some also worried about protection of the privacy of genetic information.

“What’s to stop them from mining genomic data of American samples to some unknown nefarious end?” Elaine R. Mardis, co-director of the genome sequencing center at Washington University in St. Louis, said in an e-mail.

Dr. Mardis could not specify what kind of nefarious end she imagined. But opponents of the deal cited a November article in The Atlantic saying that in the future, pathogens could be genetically engineered to attack particular individuals, including the president, based on their DNA sequences.

BGI and Complete Genomics dismissed such concerns as preposterous.

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Bits Blog: Ryan Block: Why I'm Quitting Instagram

The flap over Instagram’s changing its terms of service has not died down even weeks after its announcement and subsequent partial reversal. People are still arguing whether Instagram’s photographers will stay loyal to the service. Ryan Block, former editor in chief of AOL’s Engadget and the co-founder of the popular tech community site gdgt.com, writes in a guest post for Bits about his reasons for quitting the Facebook-owned service.

This month, surely to the chagrin of family members and friends with whom I haven’t spoken face to face for over a decade, I quit Facebook. I also suspended posting photos to Instagram, the photo sharing service that Facebook recently acquired for $715 million and where I have almost 9,000 followers. But probably not for the reasons you might think.

Facebook’s legendarily fast and loose approach to user privacy has long been something of a cliché, which is why deleting one’s account is now something of a hollow techno-political statement – the Internet equivalent to moving off the grid to a cabin in the mountains. And it’s certainly not as if Facebook has much to worry about, as no number of high-profile abandoners over the last two years have slowed the company’s ballooning growth, now at over a billion active users.

So few Facebook users took part in Facebook’s last site-governance voting, in which users were asked to approve or disapprove a number of workaday changes to its policy, that it resulted in the eventual shutdown of the site-governance balloting itself.

I also suspect that most Instagram users won’t go to the mat over the company’s proposed terms of service changes, which provided Facebook the ability to sell users’ photos. (Instagram has since backpedaled on these changes, smartly.)

Despite any nefarious behavior, real or perceived, my decision to quit was actually far less sophisticated. In the case of Facebook, I’ve simply never been fond of the service and intended to remove my largely inactive account for years. In the case of Instagram, I’ve fallen out of love with highly filtered square photos of sunsets and (often delicious-looking) plates of food.

In my search for technology products and services that somehow enrich or add value to my life, Facebook and Instagram have been a net negative not only in their usefulness, but also in other, subtle ways most people don’t often consider.

The longer users keep any of their accounts alive – even if dormant – on the dozens or hundreds of sites, services and apps registered with over the years, the greater the chances are of that data’s being used in ways we may not approve. This isn’t anything new, but as privacy policies shift and companies change hands, data we may think of as being rather personal can become highly liquid.

A decade ago, I joined one of the early social networking sites, Friendster, which struggled to find a business model and eventually collapsed as users migrated to MySpace. In the intervening years, Friendster’s brand, intellectual property (including some seminal social networking patents), and most important, user data from millions of people, were broken up or changed hands.

Now, eons later (in Internet time), Friendster lives on as an online gaming company aimed at Southeast Asian youth. I might have eventually discovered this fact by keeping up on technology news, but it turns out there was no need: one day last year, my inbox started to fill up with Friendster marketing messages for the first time in years, and I realized that my long-forgotten decade-old profile data had been sold, without my knowledge or permission, to a company I’d never heard of in Asia. And I could do nothing about it.

As technology companies work overtime to make it easier to sign up and maintain accounts, little regard is given to the long-term ownership and use of our data. After all, it’s far easier for each of us to simply forget and neglect all the random sites and services we’ve signed up for than to keep up with the innumerable changes to opaque terms of service and privacy policy documents, or monitor every merger and acquisition of every company that makes something we use. In fact, to do so would basically be a full-time job, and an excruciatingly tedious one at that.

There are other costs to letting accounts go dormant, too. The final time I loaded Facebook to click the delete button, I noticed weeks-old friend requests from my grandmother and one of my cousins. Since I long ago configured my Facebook profile to automatically ingest and posts my tweets, I’m sure it outwardly seemed as if I’m an active Facebook user. Which, of course, would make me a huge jerk for not responding to their friend requests.

I’ve also been on the other side of the same situation, having sent unrequited friend requests on other social networks like Path, never knowing whether I’ve been spurned, or whether the other party just doesn’t use the service very often.

Perhaps worst of all, in an era where we meticulously prune our online personae, services like Facebook require constant diligence and maintenance. On Twitter accounts, About.me profiles, or LinkedIn bios, at the very least users are empowered by complete control in their outward appearance. This is in contrast to Facebook and any other social tool that allows any user in its social graph to associate you with all manner of unrelated career- (or even potentially life-) changing posts or images.

We’d all be much better off simplifying our technological footprints and consolidating our trust in the few services that provide us the greatest value with the fewest unintended side effects. In the end, I’m not afraid to admit it. I’m a quitter.

And you should be, too. People wondering what there is to gain by thinning their online accounts sometimes ask: “Why quit?” Instead, I think every once in a while we should all ask ourselves: “Why stay?”

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Immigration reform could get overshadowed in Congress

WASHINGTON — The window to pass immigration laws next year is narrowing as the effort competes with a renewed debate over gun laws and the lingering fight over taxes and the budget, according to congressional staffers and outside advocates.

Key congressional committees are preparing for a package of gun control laws to be negotiated and possibly introduced in Congress during the first few months of next year. The shift would push the debate in Congress over immigration reform into the spring.

But as budget negotiations continue to stir tensions between Republicans and Democrats, and as lobbyists take to their corners over gun laws, some are concerned that the heated atmosphere could spoil the early signs of bipartisan cooperation on immigration that emerged after the election.

In phone calls over the holidays, White House officials sought to reassure advocates that the push for gun control won't distract President Obama from his promise to stump for new immigration legislation early in the year.

The uncertainty is feeding jitters that Obama may be unable to deliver on his long-standing promise to create a path to citizenship for the 11 million people in the U.S. unlawfully.

"I am concerned that an issue such as immigration where we can find strong bipartisan consensus will be demagogued and politicized, because that is the environment," said Alfonso Aguilar, a Republican strategist at the Latino Partnership for Conservative Principles, a Washington-based nonprofit.

New gun laws would probably have to pass through the Senate Judiciary Committee, the same committee that would work on an immigration bill that could be hundreds of pages long.

The tough work of hammering out a compromise over immigration in the committee would best be wrapped up by the end of June, congressional staffers said, in case one of the Supreme Court justices retires, which would set up a high-profile and time-consuming nomination process that could overshadow the immigration issue.

"Voters want to see action," said Clarissa Martinez de Castro, head of civic engagement and immigration for the National Council of La Raza. "If the American public every day has to grapple with multiple priorities, that is the least they expect from their members of Congress."

After the Dec. 14 school shooting that killed 20 children and six adults in Newtown, Conn., Obama tapped Vice President Joe Biden to head a task force that is expected to propose new gun control measures by the end of January.

"The question is: Would the Congress love to have something come along that would sidetrack immigration reform? I believe there are some members of Congress who would like that," said Eliseo Medina, secretary-treasurer of the Service Employees International Union, which represents more than 2 million workers.

"But the fact is, they won't have the luxury of ignoring it," he said.

The crowded agenda has not changed plans by advocacy groups to launch a nationwide publicity and lobbying campaign early next year to put pressure on lawmakers to support changing immigration laws.

"As horrific as the tragedy was in Connecticut, in the grand scheme of things, these issues can run on parallel tracks," said Mary Giovagnoli, director of the Immigration Policy Center, a think tank based in Washington.

"They are not in competition; they are complementary," said Angela Kelley, an expert on immigration at the Center for American Progress, a liberal think tank in Washington. "The White House can walk and chew gum, as can lawmakers."

"If [lawmakers] are working 40 hours a week, they should be able to get both done," she said.

brian.bennett@latimes.com

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Wired Science Space Photo of the Day: Hidden Flames

This composite image combines EIT images from three wavelengths (171Å, 195Å and 284Å) into one that reveals solar features unique to each wavelength. Since the EIT images come to us from the spacecraft in black and white, they are color coded for easy identification. For this image, the nearly simultaneous images from May 1998 were each given a color code (red, yellow and blue) and merged into one.

Image: NASA/SOHO [high-resolution]

Caption: NASA

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Hot spots draw believers, but not doomsday

As the sun rose from time zone to time zone across the world on Friday, there was still no sign of the world’s end — but that didn’t stop those convinced that a 5,125-year Mayan calendar predicts the apocalypse from gathering at some of the world’s purported survival hot spots.

Many of the esoterically inclined expected a new age of consciousness — others wanted a party. But, in some places said to offer salvation from the end, fewer people showed up than officials had predicted — much to the disappointment of vendors hoping to sell souvenirs.

Here are some key places being marked by the fascination over doomsday rumors:

MEXICO

In an area of Mexico that was once the ancient Mayan heartland, spiritualists gathered in the darkness before dawn on Friday to prepare white clothes, drums, conch shells and incense. They believed the sunrise would herald the birth of a new and better age as a vast cycle in the Mayan calendar comes to an end.

Many people who came to Yucatan for the occasion were already calling it “a new sun” and “a new era.”

FRANCE

According to one rumor, a rocky mountain in the French Pyrenees will be the sole place on Earth to escape destruction. A giant UFO and aliens are said to be waiting under the mountain, ready to burst through and spirit those nearby to safety. But there is bad news for those seeking salvation: French gendarmes, some on horseback, blocked outsiders from reaching the Bugarach peak and its village of some 200 people.

Eric Freysselinard, head of local government, said the security forces had “partially stopped the new age enthusiasts as well as curious people from coming to the area.”

Meanwhile, some Bugarach residents dressed up like aliens, with tinfoil costumes and funnels and fake antenna on their heads, strolling around their village Friday to make light of the rumored UFO prophecy.

RUSSIA

Doomsday rumors have prompted some people across Russia to stock up on candles, water, canned foods and other non-perishable foods. The apocalypse has proven a good business, with some shops selling survival aid packages that include soap and vodka.

In Moscow, salvation has also been promised in the underground bunker for the former Soviet dictator Josef Stalin — with a 50 percent refund if nothing happens. An underground stay was originally priced at 50,000 rubles ($ 1,625) but dropped to 15,000 ($ 490) a week ahead of the feared end.

The bunker, located 65 meters (210 feet) below ground, was designed to withstand a nuclear attack. Now home to a small museum, it has an independent electricity supply, water and food — but no more room, because the museum has already sold out all 1,000 tickets.

BRITAIN

Hundreds of people have converged on Stonehenge for an “End of the World” party that coincides with the Winter Solstice.

Arthur Uther Pendragon, Britain’s best-known druid, said he was anticipating a much larger crowd than usual at Stonehenge this year. But he doesn’t agree that the world is ending, noting that he and fellow druids believe that things happen in cycles.

“We’re looking at it more as a new beginning than an end,” he said. “We’re looking at new hope.”

Meanwhile, end-of-days parties will be held across London on Friday. One event billed as a “last supper club” is offering a three-course meal served inside an “ark.”

SERBIA

Some Serbs are saying to forget that sacred mountain in the French Pyrenees. The place to be Friday is Mount Rtanj, a pyramid-shaped peak in Serbia already drawing cultists.

According to legend, the mountain once swallowed an evil sorcerer who will be released on doomsday in a ball of fire that will hit the mountain top. The inside of the mountain will then open up, becoming a safe place to hide as the sorcerer goes on to destroy the rest of the world. In the meantime, some old coal mine shafts have been opened up as safe rooms.

On Friday a New Age group called “The Spirit of Rtanj” was holding a conference there. Participants, however, said they expect not the end of time but the start of a new time cycle. Locals turned out to sell brandy and herbs.

“There will be no tragedy, no doomsday,” said resident Dalibor Jovic. “It was supposed to happen at 12:12 and I think that time has passed. So, we can now go on with our lives and be happy to be alive.”

TURKEY

A small Turkish village known for its wines, Sirince, has also been touted as the only place after Bugarach that would escape the world’s end. But on Friday journalists and security officials outnumbered cultists. This outcome disappointed local business people who had prepared a range of doomsday products to sell, including a specially labeled Doomsday wine and Turkish delight candy whose “best before” date was Dec. 21, 2012. One restaurant prepared a special “last meal” menu that included a “heaven kebab” and “forbidden fruit dessert.”

ITALY

Another spot said to be spared: Cisternino, a beautiful small town in southern Italy in an area of trulli, traditional dry stone huts with conical roofs. The notion that Cisternino could be a safe haven at world’s end derives from an Indian guru, Babaji, who said “Cisternino will become an island” at world’s end. His followers built a community in Cisternino centered on an ashram built in 1979. Hotel bookings are up this weekend.

Mayor Donato Baccaro told the AP that the beauty of the place has inspired many foreigners to live there. “This confirms that this place has a special energy,” he said.

CHINA

A fringe Christian group has been spreading rumors about the world’s impending end, prompting Chinese authorities to detain more than 500 people this week and seize leaflets, video discs, books and other material.

Those detained are reported to be members of the group Almighty God, also called Eastern Lightning, which preaches that Jesus has reappeared as a woman in central China. Authorities in the province of Qinghai say they are waging a “severe crackdown” on the group, accusing it of attacking the Communist Party and the government.

U.S.

Dozens of Michigan schools canceled classes for thousands of students to cool off rumored threats of violence and problems related to doomsday. The fears were exacerbated by the recent shooting at a Connecticut elementary school, which “changed all of us,” the school system in Genesee County said. “Canceling school is the right thing to do.”

___

Associated Press writers Florent Bajrami in Bugarach, France; Mansur Mirovalev in Moscow; Peppino Ciraci in Cisternino, Italy; Suzan Fraser in Ankara, Turkey; Paisley Dodds in London; and Dejan Mladenovic in Mount Rtanj, Serbia, contributed to this report.

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Elwood V. Jensen, Pioneer in Breast Cancer Treatment, Dies at 92

Tony Jones/Cincinnati Enquirer, via Associated Press

Elwood V. Jensen in 2004.

Elwood V. Jensen, a medical researcher whose studies of steroid hormones led to new treatments for breast cancer that have been credited with saving or extending hundreds of thousands of lives, died on Dec. 16 in Cincinnati. He was 92.

The cause was complications of pneumonia, his son, Thomas Jensen, said.

In 2004 Dr. Jensen received the Albert Lasker Basic Medical Research Award, one of the most respected science prizes in the world.

When Dr. Jensen started his research at the University of Chicago in the 1950s, steroid hormones, which alter the functioning of cells, were thought to interact with cells through a series of chemical reactions involving enzymes.

However, Dr. Jensen used radioactive tracers to show that steroid hormones actually affect cells by binding to a specific receptor protein inside them. He first focused on the steroid hormone estrogen.

By 1968, Dr. Jensen had developed a test for the presence of estrogen receptors in breast cancer cells. He later concluded that such receptors were present in about a third of those cells.

Breast cancers that are estrogen positive, meaning they have receptors for the hormone, can be treated with medications like Tamoxifen or with other methods of inhibiting estrogen in a patient’s system, like removal of the ovaries. Women with receptor-rich breast cancers often go into remission when estrogen is blocked or removed.

By the mid-1980s, a test developed by Dr. Jensen and a colleague at the University of Chicago, Dr. Geoffrey Greene, could be used to determine the extent of estrogen receptors in breast and other cancers. That test became a standard part of care for breast cancer patients.

Scientists like Dr. Pierre Chambon and Dr. Ronald M. Evans, who shared the 2004 Lasker prize with Dr. Jensen, went on to show that many types of receptors exist. The receptors are crucial components of the cell’s control system and transmit signals in an array of vital functions, from the development of organs in the womb to the control of fat cells and the regulation of cholesterol.

Dr. Jensen’s work also led to the development of drugs that can enhance or inhibit the effects of hormones. Such drugs are used to treat prostate and other cancers.

Elwood Vernon Jensen was born in Fargo, N.D., on Jan. 13, 1920, to Eli and Vera Morris Jensen. He majored in chemistry at what was then Wittenberg College in Springfield, Ohio, and had begun graduate training in organic chemistry at the University of Chicago when World War II began.

Dr. Jensen wanted to join the Army Air Forces, but his poor vision kept him from becoming a pilot. During the war he synthesized poison gases at the University of Chicago, exposure to which twice put him in the hospital. His work on toxic chemicals, he said, inspired him to pursue biology and medicine.

Dr. Jensen studied steroid hormone chemistry at the Swiss Federal Institute of Technology on a Guggenheim Fellowship after the war. While there, he climbed the Matterhorn, one of the highest peaks in the Alps, even though he had no mountaineering experience. He often equated his successful research to the novel approach taken by Edward Whymper, the first mountaineer to reach the Matterhorn’s summit. Mr. Whymper went against conventional wisdom and scaled the mountain’s Swiss face, after twice failing to reach the summit on the Italian side.

Dr. Jensen joined the University of Chicago as an assistant professor of surgery in 1947, working closely with the Nobel laureate Charles Huggins. He became an original member of the research team at the Ben May Laboratory for Cancer Research (now the Ben May Department for Cancer Research) in 1951, and became the director after Dr. Huggins stepped down.

He came to work at the University of Cincinnati in 2002, and continued to do research there until last year.

His first wife, the former Mary Collette, died in 1982. In addition to his son, Dr. Jensen is survived by his second wife, the former Hiltrud Herborg; a daughter, Karen C. Jensen; a sister, Margaret Brennan; two grandchildren; and three great-grandchildren.

Dr. Jensen’s wife was found to have breast cancer in 2005. She had the tumor removed, he said in an interview, but tested positive for the estrogen receptor and was successfully treated with a medication that prevents estrogen synthesis.

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Senate Leaders Racing to Beat Fiscal Deadline

WASHINGTON — Senate leaders and their aides spent Saturday searching for a formula to extend tax cuts for most Americans that could win bipartisan support in the Senate and final approval in the fractious House by the new year, hoping to prevent large tax increases and budget cuts that could threaten the fragile economy.

As part of the last-minute negotiations, the lawmakers were haggling over unemployment benefits, cuts in Medicare payments to doctors, taxes on large inheritances and how to limit the impact of the alternative minimum tax, a parallel income tax system that is intended to ensure the rich pay a fair share but that is increasingly encroaching on the middle class.

President Obama said that if talks between the Senate leaders broke down, he wanted the Senate to schedule an up-or-down vote on a narrower measure that would extend only the middle-class tax breaks and unemployment benefits. The Senate majority leader, Harry Reid of Nevada, said he would schedule such a vote on Monday absent a deal.

If Congress is unable to act before the new year, Washington will effectively usher in a series of automatic tax increases and a program of drastic spending cuts that economists say could pitch the country back into recession.

The president and lawmakers put those spending cuts in place this year as draconian incentives that would force them to confront the nation’s growing debt. Now, lawmakers are trying to keep them from happening, though it seemed most likely on Saturday that the cuts, known as sequestration, would be left for the next Congress, to be sworn in this week.

“We just can’t afford a politically self-inflicted wound to our economy,” Mr. Obama said Saturday in his weekly address. “The housing market is healing, but that could stall if folks are seeing smaller paychecks. The unemployment rate is the lowest it’s been since 2008, but already families and businesses are starting to hold back because of the dysfunction they see in Washington.”

The fear of another painful economic slowdown appears to have accelerated deal-making on Capitol Hill with just 48 hours left before the so-called fiscal cliff arrives. Weeks of public sniping between Mr. Reid, the Democratic leader, and Senator Mitch McConnell of Kentucky, the Republican leader, ebbed on Friday evening with pledges of cooperation and optimism from both.

On Saturday, though, that sentiment was put to the test as 98 senators waited for word whether their leaders had come up with a proposal that might pass muster with members of both parties. The first votes in the Senate, if needed, are scheduled for Sunday afternoon.

“It’s a little like playing Russian roulette with the economy,” said Senator Mark Warner, Democrat of Virginia. “The consequences could be enormous.”

Members of Congress were mostly absent from the Capitol on Saturday, after two days of Senate votes on other matters and a day before both chambers were to reconvene. However, senior aides were working on proposals in their offices or at their homes.

Speaker John A. Boehner stopped by the Capitol briefly to see his chief of staff on Saturday afternoon. Mr. McConnell spent much of the day in his office.

Aides to Mr. Reid were expecting to receive offers from Mr. McConnell’s staff, but no progress was reported by midday. Even if the talks took a positive turn, Senate aides said, no announcement was expected before the leaders briefed their caucuses on Sunday.

The chief sticking point among lawmakers and the president continued to be how to set tax rates for the next decade and beyond. With the Bush-era tax cuts expiring, Mr. Obama and Democrats have said they want tax rates to rise on income over $250,000 a year, while Republicans want a higher threshold, perhaps at $400,000.

Democrats and Republicans are also divided on the tax on inherited estates, which currently hits inheritances over $5 million at 35 percent. On Jan. 1, it is scheduled to rise to 55 percent beginning with inheritances exceeding $1 million.

The political drama in Washington over the weekend was given greater urgency by the fear that the economic gains of the past two years could be lost if no deal is reached.

Some of the consequences of Congressional inaction would be felt almost at once on Tuesday, in employee paychecks, doctors’ offices and financial markets. Analysts said the effect would be cumulative, building over time.

An early barometer would probably be the financial markets, where skittish investors, as they have during previous Congressional cliffhangers, could send the stock market lower on fears of another prolonged period of economic distress.

In 2011, the political battles over whether to raise the nation’s borrowing limit prompted Standard & Poor’s to downgrade its rating of American debt, suggesting a higher risk of default. The Dow Jones industrial average fell 635 points in a volatile day of trading after the downgrade.

This month, traders have again nervously watched the political maneuvering in Washington, and the markets have jumped or dropped at tidbits of news from the negotiations. Two weeks ago, Ben S. Bernanke, the chairman of the Federal Reserve Board, predicted that if lawmakers failed to reach a deal, “the economy will, I think, go off the cliff.”

Immediately — regardless of whether a deal is reached — every working American’s taxes will go up because neither party is fighting to extend a Social Security payroll tax cut that has been in place for two years.

Robert Pear and Jennifer Steinhauer contributed reporting.

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Medical board appeals to public to combat prescription overdoses

In an appeal for the public's help in stemming the epidemic of prescription drug deaths, the Medical Board of California is asking people whose relatives died of overdoses to contact the board if they believe excessive prescribing or other physician misconduct contributed to the deaths.

Linda K. Whitney, the board's executive director, urged those with information about improper treatment to contact the board without delay. By law, the agency has seven years from the time of the alleged misconduct to take disciplinary action against a physician.

"The sooner we get the information, the sooner we can move forward," she said in an interview.

Whitney also said board investigators would review autopsies and other records on specific overdose deaths described in recent articles in the Los Angeles Times.

She said the board, which licenses and oversees California physicians, was acting in response to reports in The Times that documented the connection between doctors' prescribing practices and fatal overdoses involving OxyContin, Vicodin and other narcotic painkillers.

Whitney said members of the public can report concerns about excessive prescribing by calling 1-800-633-2322 or filling out and mailing a complaint form, which can be downloaded from the agency's website, http://www.mbc.ca.gov.

A revolution in treatment of chronic pain has caused a huge increase in prescriptions for pain and anxiety medications. There has been an accompanying sharp rise in prescription drug deaths over the last decade.

In response, authorities have focused on how addicts and drug dealers obtain such drugs illegally, such as by stealing from pharmacies or relatives' medicine cabinets. The Times articles reported that many fatal overdoses stem from drugs prescribed for the deceased by a doctor.

In nearly half of the prescription drug deaths in four Southern California counties from 2006 through 2011, medications prescribed by doctors caused or contributed to the death, according to an analysis of coroners' records.

Seventy-one doctors, a tiny fraction of all practicing physicians in the four counties, were associated with a disproportionate number of deaths, The Times found.

Sixteen patients of a Huntington Beach pain specialist died of overdoses from 2006 through 2011 after taking medications he prescribed. A San Diego County doctor lost 15 patients to overdoses, a Westminster physician 14, coroners' records show.

All three doctors have clean records with the medical board, and there is no evidence that board officials knew about the deaths.

That medical regulators could be unaware of clusters of fatal overdoses underscores gaps in the state's system of physician oversight.

Drugs fatalities are documented in great detail in county coroners' files, which in many cases list medications found at the scene of death, along with the name of the prescribing doctor. But medical board investigators do not review those files to look for patterns of reckless prescribing or other inappropriate treatment.

Whitney said the board would like to receive reports from county coroners on all prescription overdose deaths. State Sen. Curren Price, (D-Los Angeles), responding to the Times coverage, has promised to introduce a bill that would require such reports.

A fatal overdose does not necessarily mean a doctor did anything wrong, Whitney said. Board investigators must review patient records to determine whether physician misconduct contributed to a death, she said.

Public participation will aid such investigations, she said, because investigators can gain access to a physician's patient files more readily if a family member has granted consent.

In addition, family members may be able to contribute information about overdose deaths that is not in coroners' files. Tips from relatives could also be valuable in calling attention to previously overlooked cases, Whitney said.

Julianne D'Angelo Fellmeth, a public interest lawyer who has monitored the medical board for the state Legislature, called Whitney's announcement a "good first step," adding: "They need this information."

But Fellmeth said the board may be hindered in its investigative efforts by the effects of years of budget cuts.

The agency has fewer investigators than it did in 2001 and investigates about 40% fewer misconduct cases per year, according to board data. Over the same period, the number of licensed physicians in California has risen to more than 102,000.

"They should be actively seeking to restore the number of investigators' positions that they had before and increase those to keep up with the increase in the physician population," Fellmeth said. "It's not acceptable to have the ranks of medical investigators decrease in the face of this kind of misconduct and abuse."

From the time the board receives a complaint, it takes nearly a year on average for an investigation to be completed. In some cases, doctors under investigation for excessive prescribing have lost several patients to drug overdoses by the time the board took disciplinary action.

scott.glover@latimes.com

lisa.girion@latimes.com

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Ambitious Tome Chronicles the Rise of a New Urbanist Community

Visions of Seaside is an upcoming 608-page hardcover book that documents how the theory of New Urbanism was put into practice in the construction of a small town in Florida in 1981.

The book will contain over 1,000 drawings, photographs and diagrams created for Seaside, the first fully New Urbanist town, along with academic essays by Pulitzer Prize-winning architecture critic Paul Goldberger, Yale professor Vincent Scully, and Andrés Duany, one of the visionaries behind the community.

New Urbanism is an urban design philosophy that holds that "neighborhoods should be diverse in use and population; communities should be designed for the pedestrian and transit as well as the car; cities and towns should be shaped by physically defined and universally accessible public spaces and community institutions; urban places should be framed by architecture and landscape design that celebrate local history, climate, ecology, and building practice."

According to the book's Kickstarter page, the volume "recounts the history of the making of the town, chronicles the numerous architectural and planning schemes that have been developed for Seaside, and outlines a blueprint for moving forward over the next 25 to 50 years."

The book's author, architect Dhiru Thadani, originally conceived of the book as having 224 pages, but the overwhelming amount of materials he uncovered, along with critical essays that were generated, caused the page number to swell. This concerned his publisher, who asked Thadani to raise funds to offset production costs so that the retail price of the book would be affordable.

All images: Dhiru Thadani

Joseph Flaherty writes about design, DIY, and the intersection of physical and digital products. He designs award-winning medical devices and apps for smartphones at AgaMatrix, including the first FDA-cleared medical device that connects to the iPhone.

Read more by Joseph Flaherty

Follow @josephflaherty on Twitter.

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